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Pharmacodynamics Beta-blockers are classified as: 1-selective (cardioselective) Non-selective (1 and 2 blockade) The loss of 1 selectivity increases the likelihood of 2-mediated adverse effects, such as bronchospasm and peripheral vasoconstriction

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Gastroenterology 135:100110 Ratziu V, Charlotte F, Bernhardt C et al (2010) Long-term efficacy of rosiglitazone in nonalcoholic steatohepatitis: results of the fatty liver improvement by rosiglitazone therapy (FLIRT 2) extension trial